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HCV and HIV binding lectin, DC-SIGNR, is expressed at all stages of HCV induced liver disease
  1. G Cole,
  2. N Coleman,
  3. E Soilleux
  1. Medical Research Council Cancer Cell Unit, Hutchison/MRC Research Centre, Cambridge CB2 2XY, UK
  1. Correspondence to:
 Dr E J Soilleux
 Medical Research Council Cancer Centre Unit, Hutchison/MRC Research Centre, Cambridge CB2 2XY, UK; ejs17cam.ac.uk

Abstract

The process by which hepatitis C virus (HCV) enters cells and the reason for its hepatotropism remain obscure. Recently, the human immunodeficiency virus (HIV) binding lectins, DC-SIGN and DC-SIGNR, were shown to bind HCV. This article reports the expression of DC-SIGN and DC-SIGNR in HCV related liver disease and discusses whether these lectins, in particular DC-SIGNR, are responsible for HCV hepatotropism.

  • DC-SIGN
  • DC-SIGNR
  • hepatitis C
  • liver sinusoid
  • DC, dendritic cell
  • DC-SIGN, dendritic cell specific intercellular adhesion molecule grabbing non-integrin
  • DC-SIGNR, dendritic cell specific intercellular adhesion molecule grabbing non-integrin related molecule
  • HCV, hepatitis C virus
  • HIV, human immunodeficiency virus

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