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Interdigitating dendritic cell sarcoma of salivary gland associated lymphoid tissue not associated with HHV-8 or EBV infection

Abstract

Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare malignancy derived from professional antigen presenting cells. This report describes a case of IDCS arising in the salivary gland associated lymphoid tissue of the parotid gland of a 51 year woman, presenting with a painless neck swelling. Histologically, sheets of S100+/Ccd68+/CD45+/CD34/CD1a spindle cells were surrounded with an inflammatory infiltrate with no evidence of B or T cell clonal proliferations. No evidence of either human herpesvirus 8 or Epstein-Barr virus could be detected by quantitative polymerase chain reaction in the tumour cells with serological evidence of previous Epstein-Barr virus infection. The patient remains well and disease free 24 months after presentation without specific treatment.

  • interdigitating dendritic cell sarcoma
  • Kaposi’s sarcoma associated herpes virus
  • Epstein-Barr virus
  • EBV, Epstein-Barr virus
  • FDC, follicular dendritic cell
  • HHV, human herpesvirus
  • IDC, interdigitating dendritic cell
  • IDCS, interdigitating dendritic cell sarcoma
  • IgH, immunoglobulin heavy chain
  • PCR, polymerase chain reaction
  • TCR, T cell receptor

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