(A–D) Atypical paracortical hyperplasia pattern and (E, F) burnt out histiocytic pattern of lymphadenopathy in adult onset Still’s disease (AOSD). (A) Widened paracortical area infiltrated by many small to medium sized lymphocytes, some large immunoblasts, plasma cells, and a few eosinophils. Haematoxylin and eosin (H&E) stain; original magnification, ×400. (B) CD4 expression in about three fifths of T cells. Immunoperoxidase stain; original magnification, ×400. (C) CD8 expression in about two fifths of T cells. Immunoperoxidase stain; original magnification, ×400. (D) CD20 expression in some of the large immunoblasts and a few small lymphocytes. Immunoperoxidase stain; original magnification, ×400. (E) Vascular transformation and sinus histiocytosis with mottled appearance. H&E stain; original magnification, ×100. (F) S-100 protein expression in the aggregated histiocytes. Immunoperoxidase stain; original magnification, ×200.
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