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Nitric oxide synthase 1 and prognosis in cystic fibrosis

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Among patients with cystic fibrosis (CF) the degree of pancreatic involvement is related to the particular mutation of the cystic fibrosis transmembrane conductance regulator gene (CFTR) involved. The severity of lung, liver, or gut disease, however, is much less determined by CFTR genotype. It seems probable, therefore, that other, ‘modifier’ genes may be involved in determining prognosis. Patients …

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