Article Text

Download PDFPDF
HPV and histological status of pelvic lymph node metastases in cervical cancer: a prospective study
  1. K Lukaszuk1,
  2. J Liss2,
  3. I Wozniak1,
  4. W Sliwinski3,
  5. J Emerich3,
  6. C Wojcikowski1
  1. 1Department of Gynaecological Endocrinology, Medical University, Gdansk 80-402, Poland
  2. 2INVICTA—Laboratory of Molecular Biology, Prophylactic Centre, Gdansk 80-895, Poland
  3. 3Department of Gynaecology, Medical University, Gdansk
  1. Correspondence to:
 K Lukaszuk
 Department of Endocrinology, Medical University, Kliniczna 1A, Gdansk 80-402, Poland;


Aims: The purpose of this prospective study was to describe the incidence and distribution pattern of human papillomavirus (HPV) DNA in intraoperative dissected lymph nodes and to relate this to the pathological confirmation of metastasis.

Methods: Samples of primary cervical cancer lesions and dissected lymph nodes were obtained from women undergoing surgical treatment. The presence of HPV DNA was detected by the polymerase chain reaction.

Results: Tissue from 79 tumours and 365 lymph nodes was analysed. Metastasis to the lymph nodes was found in 19 cases. Metastasis correlated with the volume of the primary lesion, the depth of cervical and vaginal invasion, and with invasion of the corpus. HPV DNA was found in 60 of the primary lesions and 31 of the lymph nodes. The presence of HPV DNA in the lymph nodes correlated with the volume of the primary lesion and vaginal invasion.

Conclusions: The incidence of HPV DNA in lymph nodes is twice as high as that of histopathologically confirmed metastases. The risk of the presence of HPV DNA and histopathologically confirmed metastases in lymph nodes is related to certain features of the primary tumour.

  • CIP, common iliac and para-aortic
  • EIO, external iliac and obturator
  • HPV, human papillomavirus
  • PCR, polymerase chain reaction

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.