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Correspondence
Type A intracytoplasmic inclusions in human cowpox infection
  1. S D Lawn1,
  2. S Holwill2
  1. 1Department of Cellular and Molecular Medicine: Infectious Diseases, St George’s Hospital Medical School, London SW17 ORE, UK; stevelawn@yahoo.co.uk
  2. 2Department of Histopathology, St George’s Hospital Medical School

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      Replication of poxviruses results in the development of intracytoplasmic inclusions that may be visible by light microscopy. Kato et al (1959) classified these according to their morphology, staining properties, and rate of accumulation.1 Type B inclusions are basophilic and occur early in the viral replication cycle. They represent the actual site of viral replication in the cytoplasm and may be seen in all productive poxvirus infections. In contrast, type A inclusions are large, well defined, eosinophilic bodies that develop late in the viral replication cycle. They are composed entirely of a single …

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