Abstract

Aims: To investigate the smooth muscle nature of the stromal cells in the capsule of hepatocellular carcinomas.

Methods: Immunohistochemical analysis using monoclonal antibody to high molecular weight caldesmon (HCD), a highly specific marker for smooth muscle cells, was performed in 33 encapsulated hepatocellular carcinomas and adjacent hepatic tissues.

Results: HCD positive stromal cells were detected in the capsule of 21 of the 33 hepatocellular carcinomas examined.

Conclusions: The capsule of hepatocellular carcinomas contains smooth muscle cells.