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Increased neutrophil apoptosis in chronic fatigue syndrome
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  1. G Kennedy,
  2. V Spence,
  3. C Underwood,
  4. J J F Belch
  1. Vascular Diseases Research Unit, University Department of Medicine, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
  1. Correspondence to:
 Dr G Kennedy
 Vascular Diseases Research Unit, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK; g.kirkdundee.ac.uk

Abstract

Background/Aims: Many patients with chronic fatigue syndrome (CFS) have symptoms that are consistent with an underlying viral or toxic illness. Because increased neutrophil apoptosis occurs in patients with infection, this study examined whether this phenomenon also occurs in patients with CFS.

Methods: Apoptosis was assessed in patients with CFS in conjunction with concentrations of the anti-inflammatory cytokine, transforming growth factor β1 (TGFβ1).

Results: The 47 patients with CFS had higher numbers of apoptotic neutrophils, lower numbers of viable neutrophils, increased annexin V binding, and increased expression of the death receptor, tumour necrosis factor receptor-I, on their neutrophils than did the 34 healthy controls. Patients with CFS also had raised concentrations of active TGFβ1 (p < 0.005).

Conclusions: These findings provide new evidence that patients with CFS have an underlying detectable abnormality in their immune cells.

  • CFS, chronic fatigue syndrome
  • PI, propidium iodide
  • PPP, platelet poor plasma
  • TGFβ1, transforming growth factor β1
  • TNFRI, tumour necrosis factor receptor I
  • neutrophils
  • apoptosis
  • chronic fatigue syndrome

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