This book is a 510 page, hard cover issue covering proteomic methods and their applications in molecular biology, a subject that is of interest to many molecular scientists. It consists of four major sections, which include both colour and black and white illustrations. The first major section deals with the general techniques of proteomics and specific aspects of the technology. The second section concentrates on post-translational modifications, variants, and isoforms. Here, the characterisation of protein isoforms is discussed at length.

The book is written by a group of well recognised scientists who describe a wide range of state of the art techniques used for the identification of and analysis of a variety of proteins that are expressed in the cell.

The techniques described vary from very general to highly specific ones that are used for data analysis and the investigation of post-translational modifications. In addition, several methods describing how the application of proteomics can be used to identify new drugs and markers for cancer are also discussed. The methods for each protocol are described in great detail, together with potential trouble shooting approaches, which may be necessary when encountering problems.

This book is a well written, fully referenced text on proteomic methods, which provides an excellent guide to any scientist working in the field. In addition, the book also demonstrates how proteomic methods might provide a clearer insight into complex biological systems ranging from plants to humans in the amelioration of disease. Furthermore, this technology could provide a means for better and more effective drug development.

The editor has produced a remarkable book, which is ideal for any scientist working in the proteomics field.