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Statin precipitated lactic acidosis?
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  • Published on:
    Response to Dr Kruger
    • Tim M Reynolds, Consultant Chemical Pathologist
    • Other Contributors:
      • Neale R, Saweirs W

    Dear Editor

    In response to Dr Kruger, we provide extra minor details that had been omitted for reasons of word count.

    • As described, dyspnoea had been present and worsening for 6 weeks. The blood gas results cited were from 5 days after the date of hospital admission but were not significantly different from gases taken on 2 earlier occasions during the admission. The results cited were the ones tha...
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    Conflict of Interest:
    None declared.
  • Published on:
    Statin precipitated lactic acidosis: A very big question mark
    • Peter S Kruger, Intensive Care Specialist
    • Other Contributors:
      • Bala Venkatesh and Thomas J Morgan

    Dear Editor

    We read with interest the report on postulated atorvastatin induced lactic acidosis [1]. In our view, the arguments outlined by its authors do not support this hypothesis at all, for the reasons outlined below:

    a) The patient clearly had a mixed acid-base disturbance (combined respiratory alkalosis and metabolic acidosis, as evidenced by the normal pH of 7.39 coupled with severe hypocapnia)....

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    Conflict of Interest:
    None declared.