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Mitochondrial DNA haplotyping revealed the presence of mixed up benign and neoplastic tissue sections from two individuals on the same prostatic biopsy slide
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  • Published on:
    Author's reply to Parr et al.

    Dear Editor,

    Setting up standards when interpreting mtDNA CR sequence data from tumors.

    We agree with Parr et al.[1] on the importance to compare the mtDNA sequence data of our recent case report [2] (a divergence of 7 homoplasmic nucleotide positions within the 16024-16365 segment of the HV1 region between two morphologically different tissue sections found on the same slide) with the available...

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    Conflict of Interest:
    None declared.
  • Published on:
    MtDNA haplotyping of pathology specimens
    • Ryan L. Parr, V. P. Research and Development
    • Other Contributors:
      • Gabriel D. Dakubo, Jennifer Maki

    Dear Editor

    Alonso et al [1] recommend the use of mitochondrial genetic typing to exclude the possibility of tissue carryover artifacts in situations where low DNA content and high degradation may compromise conventional short tandem repeat typing. They studied archived presurgical hematoxylin and eosin stained needle biopsy sections from the same slide to ascertain the authentic source of the malignant and...

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    Conflict of Interest:
    None declared.