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Poorly differentiated hepatocellular carcinoma with unusual tubular structures
  1. J Yamaguchi1,
  2. H Ojima2,
  3. N Hiraoka2,
  4. T Hasegawa3
  1. 1Clinical Laboratory Division, National Cancer Centre Hospital, Tokyo, Japan
  2. 2Pathology Division, National Cancer Centre Research Institute, Tokyo, Japan
  3. 3Department of Clinical Pathology, Sapporo Medical University School of Medicine, Sapporo060-8543, Japan;

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The patient was a 70 year old woman. A tumour in liver segment 8 arose in a background of cirrhotic liver with chronic hepatitis C and reached a size of 6.0 cm in six months. The patient’s serum concentration was raised (17101 ng/ml), and the tumour was suspected to be hepatocellular carcinoma (HCC) based on various image findings. An extended liver anterior segmentectomy was performed, and serum α fetoprotein returned to normal immediately after surgery.

Although the macroscopic findings were compatible with conventional HCC (fig 1A), the histology of the tumour was atypical—the tumour cells mainly formed irregular tubular structures filled with a bloody/serous or bloody fluid (fig 1B), and small tubular or acinar-like structures were also found (fig 1C). Solid structures were seen in a small portion of the tumour (fig 1D), …

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  • The patient gave informed consent for this letter to be published.