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Extramedullary myeloid tumour (EMMT) of the gallbladder
  1. H Ojima1,
  2. T Hasegawa1,
  3. Y Matsuno1,
  4. M Sakamoto2
  1. 1Pathology Division, National Cancer Centre Research Institute and Hospital, 5–1–1 Tsukiji, Chuo-ku, Tokyo 101–0045, Japan
  2. 2Department of Pathology, Keio University School of Medicine, Tokyo 160-0016, Japan
  1. Correspondence to:
 Dr T Hasegawa
 Pathology Division, National Cancer Centre Research Institute, 5–1–1 Tsukiji, Chuo-ku, Tokyo 101–0045, Japan;


This report describes a rare case of an extramedullary myeloid tumour (EMMT) of the gallbladder in a patient without leukaemia. A 33 year old man visited a local hospital because of jaundice. Abdominal computed tomography revealed a tumorous mass measuring 6.0 × 4.5 cm and involving the entire gallbladder. A percutaneous needle biopsy was attempted, but because adenocarcinoma could not be completely ruled out, the use of undue force was considered dangerous. Under a preoperative diagnosis of gallbladder carcinoma, a hepatopancreatoduodenectomy was performed. The tumour cells exhibited various amounts of eosinophilic cytoplasm, had medium sized round nuclei with indentation and grooving, and were strongly immunoreactive for myeloperoxidase, CD43, and c-kit protein (CD117). After surgery, the patient underwent combination chemotherapy as prescribed for cases of acute myeloblastic leukaemia. The patient did not develop acute leukaemia during a follow up period of four years. In conclusion, a correct diagnosis of EMMT can be made using appropriate immunohistochemical staining.

  • EMMET, extramedullary myeloid tumour
  • MPO, myeloperoxidase

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