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Case report
Perianal apocrine adenocarcinoma arising in a benign apocrine adenoma; first case report and review of the literature
  1. K N MacNeill1,
  2. R H Riddell2,
  3. D Ghazarian3
  1. 1Department of Laboratory Medicine and Pathology, University of Toronto, Toronto, Ontario M9G 1L5, Canada
  2. 2Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
  3. 3Department of Pathology, University Health Network, Toronto, Ontario M5G 2M9, Canada
  1. Correspondence to:
 Dr K N MacNeill
 University of Toronto, Toronto, Ontario, Canada; karenmacneillyahoo.com

Abstract

Benign apocrine lesions have been described in the anogenital region, although according to the World Health Organisation convincing examples of anal apocrine adenocarcinomas have not been published. This report describes the case of an invasive apocrine adenocarcinoma arising in a benign adenoma in the perianal region of a 45 year old woman. The origin and invasiveness are supported by histological and immunohistochemical studies.

  • ER, oestrogen receptor
  • MSA, muscle specific actin
  • PR, progesterone receptor

https://doi.org/10.1136/jcp.2004.021394

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