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Cytoplasmic fragments of leukaemic cells masquerading as platelets in an automated haematology analyser
  1. N Kakkar1,
  2. G Garg2
  1. 1Department of Pathology, Christian Medical College and Hospital, Ludhiana-141 008, Punjab, India;
  2. 2Department of Pathology, Christian Medical College and Hospital, Ludhiana

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    The accuracy of platelet counts has been a major achievement of automation in haematology laboratories. However, a large array of interfering substances can erroneously increase automated platelet counts. Thrombocytopenia necessitating transfusion can be overlooked in the presence of a spurious increase in the platelet count. Therefore, automated parameters require careful interpretation with respect to the clinical profile of the patients, along with blood smear examination.1

    A 10 year old boy presented with fever and lethargy of two week’s duration. He was pale, and had cervical and axillary lymphadenopathy, with moderate hepatosplenomegaly. The automated complete blood count carried out on an Advia-60 machine (Bayer, Baroda, India), a three part differential analyser, revealed a haemoglobin …

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