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Massive myeloid sarcoma affecting the central nervous system, mediastinum, retroperitoneum, liver, and rectum associated with acute myeloblastic leukaemia: a case report
  1. C R Best-Aguilera1,
  2. M Vazquez-Del Mercado2,
  3. J F Muñoz-Valle2,
  4. L Herrera-Zarate1,
  5. R E Navarro-Hernandez2,
  6. B T Martin-Marquez2,
  7. E Oregon-Romero2,
  8. S Ruiz-Quezada2,
  9. G M Bonilla2,
  10. A Lomeli-Guerrero1
  1. 1Departmento de Hematologia, Hospital General de Occidente, SSJ, Zapopan, Jalisco, 45170 México
  2. 2Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44290 Mexico
  1. Correspondence to:
 Dr C R Best-Aguilera
 Av. Zoquipan, 1050 Zapopan Jal., México, 45175;


Myeloid sarcomas are extramedullary tumours with granulocytic precursors. When associated with acute myelogenous leukaemia (AML), these tumours usually affect no more than two different extramedullary regions. This report describes a myeloid sarcoma associated with AML with tumour formation at five anatomical sites. The patient was a 37 year old man admitted in September 1999 with a two month history of weight loss, symptoms of anaemia, rectal bleeding, and left facial nerve palsy. The anatomical sites affected were: the rectum, the right lobe of the liver, the mediastinum, the retroperitoneum, and the central nervous system. A bone marrow smear was compatible with AML M2. Flow cytometry showed that the peripheral blood was positive for CD4, CD11, CD13, CD14, CD33, CD45, and HLA-DR. A karyotypic study of the bone marrow revealed an 8;21 translocation. The presence of multiple solid tumours in AML is a rare event. Enhanced expression of cell adhesion molecules may be the reason why some patients develop myeloid sarcomas.

  • AML, acute myelogenous leukaemia
  • acute myelogenous leukaemia
  • myeloid sarcoma

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