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We read with interest the article by Hilbe et al concerning the contribution of endothelial progenitor cells (EPCs) to the vasculature in non-small cell lung cancer (NSCLC).1 In their study, the authors conclude that “increased numbers of CD133 positive EPCs can be found in NSCLC tissue and these cells seem to contribute to the formation of capillaries”. Although it is interesting and worthy of further study, in our view, the evidence presented in their paper is unconvincing. However, the problems are not apparent to readers unfamiliar with the background or pitfalls of this specialised topic.
The development of a vascular network plays a crucial role in the development and function of normal tissues and organs, in addition to tumour …