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Endothelial progenitor cells in non-small cell lung cancer
  1. B Dome1,
  2. J Timar2,
  3. G Ostoros3,
  4. S Paku4
  1. 1Department of Pulmonary Oncology, National Institute of Pulmonology, Piheno u 1–3, Budapest, H-1529, Hungary;
  2. 2National Institute of Oncology, H-1122, Ráth Gy. u. 7–9, Budapest, Hungary
  3. 3Department of Pulmonary Oncology, National Institute of Pulmonology
  4. 4First Institute of Pathology and Experimental Cancer Research, Semmelweis University, H-1085, Ulloi ut26, Budapest, Hungary

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    We read with interest the article by Hilbe et al concerning the contribution of endothelial progenitor cells (EPCs) to the vasculature in non-small cell lung cancer (NSCLC).1 In their study, the authors conclude that “increased numbers of CD133 positive EPCs can be found in NSCLC tissue and these cells seem to contribute to the formation of capillaries”. Although it is interesting and worthy of further study, in our view, the evidence presented in their paper is unconvincing. However, the problems are not apparent to readers unfamiliar with the background or pitfalls of this specialised topic.

    The development of a vascular network plays a crucial role in the development and function of normal tissues and organs, in addition to tumour …

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