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Case report
Squamous cell carcinoma arising in a tall cell papillary carcinoma of the thyroid
  1. J Sutak1,
  2. J S Armstrong1,
  3. J E Rusby2
  1. 1Department of Histopathology, Great Western Hospital, Swindon and Marlborough NHS Trust, Marlborough Road, Swindon SN3 6BB, UK
  2. 2Department of General Surgery, Great Western Hospital, Swindon and Marlborough NHS Trust
  1. Correspondence to:
 Dr J Armstrong
 Department of Pathology, Great Western Hospital, Swindon and Marlborough NHS Trust, Marlborough Road, Swindon SN3 6BB, UK; Janette.Armstrongsmnhst.swest.nhs.uk

Abstract

Transformation of differentiated thyroid cancer into poorly differentiated carcinoma is rare. This report describes a case in which preoperative fine needle aspiration suggested a squamous cell carcinoma whereas needle core biopsy favoured an undifferentiated carcinoma of probable thyroid origin. Histology of the subsequent total thyroidectomy specimen revealed a biphasic tumour comprising areas of tall cell papillary carcinoma merging with moderately to poorly differentiated squamous cell carcinoma. The immunohistochemical findings are discussed in detail.

  • thyroid
  • tall cell papillary carcinoma
  • squamous cell carcinoma

https://doi.org/10.1136/jcp.2004.021451

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