Figure 1

Figure 1

 Transmission electron microscopy (TEM) images of platelets from (A) a normal control and (B, C) patient 4 under TEM (original magnifications: A, ×12 930; B, ×27 800; C, ×12 930). The patient’s platelets contained dense granules of different shapes and sizes (B, C) and amorphous cytoplasmic inclusions (single arrow) with (B, double arrow) and without (C, single arrow) a myelin figure; an intact mitochondrion (m) and microtubuli (MT) are also seen. Vacuolar spaces (V) with amorphous electron dense material (B, C), a Golgi complex (arrow), and a platelet that is undergoing spontaneous release are striking (C).