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Pancreatic polypeptide cell hyperplasia of the pancreas
  1. R Albazaz1,
  2. P E Da Costa2,
  3. C S Verbeke1
  1. 1Department of Histopathology, St James’s University Hospital Leeds, Leeds, UK
  2. 2Airedale General Hospital, Knightley, West Yorkshire, UK
  1. Correspondence to:
 C S Verbeke
 Department of Histopathology, St James’s University Hospital, Beckett Street, Leeds LS9 7TF, UK;Caroline.Verbeke{at}


A case of pancreatic polypeptide cell hyperplasia in a 76-year-old man who presented with subacute bowel pseudo-obstruction is reported. A computed tomography scan incidentally showed a pancreatic head lesion that was resected by pancreaticoduodenectomy. Histological examination showed expansion of the endocrine pancreas with increased numbers of pancreatic polypeptide cells in irregularly enlarged islets, ragged endocrine cell clusters, ductulo-insular complexes and microadenomas. The clinicopathological features of this rare and poorly understood condition are discussed.

  • DIC, ductulo-insular complex
  • MEN I, multiple endocrine neoplasia type 1
  • PET, pancreatic endocrine tumour
  • PPCH, pancreatic polypeptide cell hyperplasia

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  • Competing interests: None.