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e19a2 BCR–ABL fusion transcript in typical chronic myeloid leukaemia: a report of two cases
  1. B C Mondal1,
  2. S Majumdar1,
  3. U B Dasgupta1,
  4. U Chaudhuri2,
  5. P Chakrabarti2,
  6. S Bhattacharyya2
  1. 1Department of Biophysics, Molecular Biology and Genetics, University of Calcutta, Kolkata, India
  2. 2Institute of Haematology and Transfusion Medicine, Kolkata
  1. Correspondence to:
 U B Dasgupta
 Department of Biophysics, Molecular Biology and Genetics, University of Calcutta, 92 APC Road, Kolkata 700009, India; ubdgh{at}


This report describes two patients with chronic myeloid leukaemia (CML): one of them developed accelerated phase CML and died 8 years after diagnosis and the other is at the chronic phase. Sequence analysis of reverse transcription-polymerase chain reaction products showed the presence of BCR–ABL fusion transcript e19a2. This finding suggests that CML carrying μ-BCR breakpoint may exhibit a clinical course similar to typical CML.

  • CML, chronic myeloid leukaemia

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  • Competing interests: None declared.