Background: Vascular tumours such as Kaposi’s sarcoma and capillary haemangioma are characterised by abnormal vascularisation and proliferation of endothelial cells or neoplastic cells. Adrenomedullin, a potent vasodilative peptide, and its receptor, calcitonin receptor-like receptor (CRLR), play an important part in angiogenesis.
Aim: To establish whether this system also plays a part in vascular diseases, showing abnormal proliferation such as vascular tumours.
Methods: CRLR expression was investigated in several specimens of Kaposi’s sarcoma and other vascular tumours, using immunohistochemical analysis with a previously described CRLR-specific polyclonal antibody and reverse transcriptase-polymerase chain reaction.
Results: Intense and specific CRLR-immunoreactive staining of neoplastic cells was observed in all specimens, which was of greater intensity than similar staining of adjacent normal endothelium.
Conclusions: CRLR is expressed in vascular tumours and, with adrenomedullin, may have a role in neoplastic vascular growth.
- ADM, adrenomedullin
- CRLR, calcitonin receptor-like receptor
- CRLR-LI, calcitonin receptor-like receptor-like immunoreactivity
- PCR, polymerase chain reaction
- RAMP, receptor activity-modifying protein
- VEGF, vascular endothelial-derived growth factor
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Competing interests: None declared.