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Expression of calcitonin receptor-like receptor in human vascular tumours
  1. S Hagner1,
  2. U Stahl2,
  3. T Grimm3,
  4. M Stürzl4,
  5. R E Lang1
  1. 1Institute of Physiology, Philipps-University Marburg, Marburg, Germany
  2. 2Institute of Pathology and Zytology, Wetzlar, Germany
  3. 3Institute of Molecular Virology, Neuherberg, Germany
  4. 4Molecular and Experimental Surgery, Department of Surgery, University of Erlangen-Nürnberg, Nürnberg, Germany
  1. Correspondence to:
 S Hagner
 Institut für Normale und Pathologische Physiologie, Philipps-Universität Marburg, Deutschhausstr 2, D-35037 Marburg, Germany; hagnerbe{at}staff.uni-marburg.de

Abstract

Background: Vascular tumours such as Kaposi’s sarcoma and capillary haemangioma are characterised by abnormal vascularisation and proliferation of endothelial cells or neoplastic cells. Adrenomedullin, a potent vasodilative peptide, and its receptor, calcitonin receptor-like receptor (CRLR), play an important part in angiogenesis.

Aim: To establish whether this system also plays a part in vascular diseases, showing abnormal proliferation such as vascular tumours.

Methods: CRLR expression was investigated in several specimens of Kaposi’s sarcoma and other vascular tumours, using immunohistochemical analysis with a previously described CRLR-specific polyclonal antibody and reverse transcriptase-polymerase chain reaction.

Results: Intense and specific CRLR-immunoreactive staining of neoplastic cells was observed in all specimens, which was of greater intensity than similar staining of adjacent normal endothelium.

Conclusions: CRLR is expressed in vascular tumours and, with adrenomedullin, may have a role in neoplastic vascular growth.

  • ADM, adrenomedullin
  • CRLR, calcitonin receptor-like receptor
  • CRLR-LI, calcitonin receptor-like receptor-like immunoreactivity
  • PCR, polymerase chain reaction
  • RAMP, receptor activity-modifying protein
  • VEGF, vascular endothelial-derived growth factor

https://doi.org/10.1136/jcp.2005.026930

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    Footnotes

    • Competing interests: None declared.