Statistics from Altmetric.com
Splenic marginal zone lymphoma (SMZL) is defined in the World Health Organization (WHO) classification as a B cell lymphoma comprising small lymphocytes that surround and replace the splenic white pulp and merge with a peripheral (marginal) zone of larger cells, leading to a biphasic zonal pattern. The tumour involves the spleen, splenic hilar lymph node, bone marrow and often, peripheral blood. Recently, Mollejo et al1 proposed a putative diffuse variant of SMZL with predominantly red-pulp involvement, absence of follicular replacement and a monomorphous population of tumour cells resembling marginal zone B cells, with scattered nucleolated blast cells. They found high p53 expression in all four patients, with p53 gene mutation in two.
Here, we report a case similar to that reported by Mollejo et al, without p53 overexpression. A 34-year-old woman presented …
Competing interests: None declared.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.