Article Text

Download PDFPDF
Malignant histiocytosis: a case report of a rare tumour presenting with spontaneous splenic rupture
  1. S E Low,
  2. J S Stafford
  1. Department of Histopathology, Leighton Hospital, Crewe, UK
  1. Correspondence to:
 Dr S E Low
 Department of Histopathology, Leighton Hospital, Crewe CW1 4QJ, UK; suenn10{at}


Malignant histiocytosis is a rare invasive proliferation of neoplastic histiocytes. Cases previously reported as malignant histiocytosis were shown to be lymphomas of T or B lineage, especially anaplastic large-cell lymphomas. A case of malignant histiocytosis is described, in which a patient presenting with symptoms suggestive of pneumonia suddenly deteriorated and died. At autopsy, a large quantity of fresh blood, originating from several ruptured nodules on the enlarged spleen, was seen in the peritoneal cavity. Extensive infiltration by pleomorphic tumour cells and erythrophagocytosis by tumour cells were seen on histological examination of the spleen. Immunohistochemical analysis and staining were carried out. This is the second reported case of malignant histiocytosis presenting with spontaneous splenic rupture.

  • EMA, epithelial membrane antigen

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Competing interests: None declared.

  • Informed consent was received for publication of this case report.