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Mixed epithelial and stromal tumour of the kidney with luteinised ovarian stroma
  1. C Buritica1,
  2. M Serrano1,
  3. A Zuluaga2,
  4. M Arrabal2,
  5. S Regauer3,
  6. F F Nogales1
  1. 1Department of Pathology, University Hospital, Granada, Spain
  2. 2Department of Urology, University Hospital, Granada, Spain
  3. 3Institute of Pathology, Medical University Graz, Graz, Austria
  1. Correspondence to:
    F F Nogales
    Departamento de Anatomía Patológica, Facultad de Medicina, University of Granada, 18012 Granada, Spain; fnogales{at}


We report a case of a 9-cm mixed epithelial and stromal tumour of the kidney in an obese 70-year-old woman with diabetes. The ovarian-type stroma had a spindle cell component that was positive for progesterone receptors and had the hitherto unreported presence of abundant foci of luteinised stromal cells with characteristic immunohistochemical positivity to α-inhibin, calretinin, aromatase and gonadotropin-releasing hormone (GnRH) receptors. We conclude that the stromal component is identical to ovarian cortical stroma.

We believe that ovarian-type stroma occurs in extragenital tumours as a result of an epithelial–stromal interaction in an environment of hormonal hyperstimulation.

  • GnRH, gonadotropin-releasing hormone
  • MEST, mixed epithelial and stromal tumour
  • OTS, ovarian-type stroma

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  • Competing interests: None declared.

  • Informed consent has been received for publication of this information