Article Text

Download PDFPDF
Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and lymphoproliferative disorders
  1. M-Q Du1,
  2. C M Bacon1,
  3. P G Isaacson2
  1. 1
    Department of Pathology, University of Cambridge, Cambridge, UK
  2. 2
    Department of Histopathology, University College London, UK
  1. Professor Ming-Qing Du, Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Box 231, Level 3, Lab Block, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK; mqd20{at}


Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), is a recent addition to the list of human viruses that are directly associated with lymphoproliferative disorders. KSHV was first shown to be involved in multicentric Castleman disease and primary effusion lymphoma (PEL). Subsequently, the virus was identified in solid lymphomas, often of extranodal sites, with morphological and immunophenotypic characteristics similar to those of PEL, and in other lymphoproliferative disorders with heterogeneous clinicopathological presentations. The recent advances in our understanding of the histology, immunophenotype and pathogenesis of these KSHV-associated lymphoproliferative disorders are reviewed.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Competing interests: None declared.

  • Funding: The research work performed in our laboratories and described in this review is supported by grants from the Leukaemia Research Fund. Chris Bacon is supported by a Senior Clinician Scientist Fellowship from the Health Foundation, the Royal College of Pathologists and the Pathological Society of Great Britain and Ireland.