Article Text

Download PDFPDF
Molecular aspects of HTLV-I infection and adult T-cell leukaemia/lymphoma
  1. G P Taylor
  1. Infectious Diseases Section, Division of Medicine Faculty, Imperial College London, London, UK
  1. Dr G P Taylor, Infectious Diseases Section, Division of Medicine Faculty, St Mary’s Campus, Imperial College London, London SW7 2AZ, UK; g.p.taylor{at}


Human T-cell lymphotropic virus-I (HTLV-I) is the cause of adult T-cell leukaemia/lymphoma. Various viral proteins, especially, but not exclusively, Tax have been implicated in oncogenesis, mostly through in vitro studies. Tax transactivates a large and apparently ever expanding list of human genes through transcriptional factors. Elucidating not only the pathways but also the timing of action of HTLV proteins is important for understanding the pathogenesis and development of new treatments.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Competing interests: None declared.