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Original article
Survivin promoter polymorphism and cervical carcinogenesis
  1. A A Borbély1,
  2. M Murvai2,
  3. K Szarka1,
  4. J Kónya1,
  5. L Gergely2,
  6. Z Hernádi3,
  7. G Veress1
  1. 1Department of Medical Microbiology, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary
  2. 2Tumour Virus Research Group of the Hungarian Academy of Sciences, Debrecen, Hungary
  3. 3Department of Obstetrics and Gynecology, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary
  1. Correspondence to:
 Dr G Veress
 Department of Medical Microbiology, Medical and Health Science Centre, University of Debrecen, H-4012 Debrecen, POB 17, Hungary;veregy{at}dote.hu

Abstract

Background: Survivin, a novel member of the inhibitor of apoptosis family, plays an important role in cell cycle regulation. A common polymorphism at the survivin gene promoter (G/C at position 31) was shown to be correlated with survivin gene expression in cancer cell lines.

Aim: To investigate whether this polymorphism could be involved in the development of human papillomavirus (HPV)-associated cervical carcinoma.

Methods: Survivin promoter polymorphism was detected in patients with cervical cancer, in patients with equivocal cytological atypia and in a control population using polymerase chain reaction (PCR-restriction fragment length polymorphism (RFLP) and PCR-single strand conformation polymorphism analysis. HPV was typed in patients with cervical cancer and cytological atypia using PCR-RFLP.

Results: No statistically significant differences were found in the genotype distributions of the survivin promoter variants among our study groups.

Conclusions: The survivin promoter polymorphism at position 31 may not represent an increased risk for the development of cervical cancer, at least in the population studied here.

  • ASC, atypical squamous cells
  • CDE, cycle-dependent element
  • CHR, cycle homology region
  • HPV, human papillomavirus
  • PCR, polymerase chain reaction
  • RFLP, restriction fragment length polymorphism
  • SSCP, single-strand conformation polymorphism

https://doi.org/10.1136/jcp.2006.037804

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    Footnotes

    • Published Online First 19 May 2006

    • Funding: This study was supported by grants from the Hungarian Scientific Research Fund (OTKA T049191 and T046608).

    • Competing interests: None.