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Survivin promoter polymorphism and cervical carcinogenesis


Background: Survivin, a novel member of the inhibitor of apoptosis family, plays an important role in cell cycle regulation. A common polymorphism at the survivin gene promoter (G/C at position 31) was shown to be correlated with survivin gene expression in cancer cell lines.

Aim: To investigate whether this polymorphism could be involved in the development of human papillomavirus (HPV)-associated cervical carcinoma.

Methods: Survivin promoter polymorphism was detected in patients with cervical cancer, in patients with equivocal cytological atypia and in a control population using polymerase chain reaction (PCR-restriction fragment length polymorphism (RFLP) and PCR-single strand conformation polymorphism analysis. HPV was typed in patients with cervical cancer and cytological atypia using PCR-RFLP.

Results: No statistically significant differences were found in the genotype distributions of the survivin promoter variants among our study groups.

Conclusions: The survivin promoter polymorphism at position 31 may not represent an increased risk for the development of cervical cancer, at least in the population studied here.

  • ASC, atypical squamous cells
  • CDE, cycle-dependent element
  • CHR, cycle homology region
  • HPV, human papillomavirus
  • PCR, polymerase chain reaction
  • RFLP, restriction fragment length polymorphism
  • SSCP, single-strand conformation polymorphism

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