We read the paper of Matull et al¹ on the biochemical markers of acute pancreatitis with much interest. We would, however, like to comment on some aspects that could be misleading.

First, absolute cut-off points as part of diagnosis or risk prediction need to be employed with great care.² This is especially true for enzyme assays such as alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase and amylase. For example, more than 200 methods …