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Limitations of transferability of absolute cut-points in non-standardised assays
  1. Adie Viljoen,
  2. Patrick J Twomey
  1. Department of Clinical Biochemistry Lister Hospital Coreys Mill Lane Stevenage, UK
  1. Correspondence to:
 Dr A Viljoen
 Department of Clinical Biochemistry, Lister Hospital, Coreys Mill Lane, Stevenage, SG1 4AB, UK;adie.viljoen{at}

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We read the paper of Matull et al1 on the biochemical markers of acute pancreatitis with much interest. We would, however, like to comment on some aspects that could be misleading.

First, absolute cut-off points as part of diagnosis or risk prediction need to be employed with great care.2 This is especially true for enzyme assays such as alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase and amylase. For example, more than 200 methods …

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  • Competing interests: None declared.