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Two cases of cytokeratin positivity in atypical fibroxanthoma
  1. Cheryl Bansal1,
  2. Prasanna Sinkre2,
  3. David Stewart2,
  4. Clay J Cockerell2
  1. 1Department of Dermatology, Drexel University College of Medicine, Philadelphia, Pennslyvania, USA
  2. 2Department of Dermatology, Division of Dermatopathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
  1. Correspondence to:
 C Bansal
 Drexel University College of Medicine, 2967 Schoolhouse Lane, Apt C-602A, Philadelphia, PA 19144, USA; cb59{at}

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Atypical fibroxanthoma (AFX) is a pleomorphic tumour, first described by Helwig in 1961.1 AFX was thought to be a superficial form of malignant fibrous histiocytoma, but some describe AFX as a reactive lesion that can be confused with pleomorphic carcinomas. Clinically, AFX presents as a 1–2 cm rapidly growing, dome-shaped, polypoid nodule or plaque which may crust or ulcerate.2 AFX is a low-grade sarcoma and is usually cured by excision; however, recurrence and rare metastases have been reported.3

Histological examination shows a dome-shaped …

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