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Mucosa-associated lymphoid tissue (MALT) lymphoma is associated with recurrent chromosomal translocations t(11;18)(q21;q21), t(14;18)(q32;q21), t(1;14)(p22;q32) and t(3;14)(p14.1;q32).1,2 While t(11;18)(q21;q21) fuses the N-terminus of the API2 (11q21) gene to the C-terminus of the MALT1 (18q21) gene and generates a functional API2–MALT1 product, t(1;14)(p22;q32), t(14;18)(q32;q21) and t(3;14)(p14.1;q32) bring the BCL10(1p22), MALT1 (18q21) and FOXP1(3p14) genes, respectively, under the control of the immunoglobulin heavy chain (IGH, 14q32) enhancer, leading to their overexpression.1 Interestingly, the oncogenic activity of the first three chromosomal translocations is linked by the physiological role of BCL10 and MALT1 in antigen receptor-mediated nuclear factor kappa B (NFκB) activation.1
Primary pulmonary MALT lymphomas show heterogeneous cytogenetic abnormalities, including aneuploidy and translocations. Among the translocations described in MALT lymphoma of this site, t(11;18)(q21;q21) is the most common, occurring in up to 50% of cases, and t(14;18)(q32;q21) and t(1;14)(p22;q32) are relatively rare.3–5 The overall incidence of t(1;14)(p22;q32) is approximately 3% in MALT lymphomas of different sites, and can be up to 10% in pulmonary cases.4–6 Recently, Achuthan et al7 reported t(1;2)(p22;p12) involving the BCL10 and the immunoglobulin kappa (IGK) light chain genes as a novel translocation in a gastric MALT lymphoma. Here we report the first case of pulmonary MALT lymphoma with this translocation, indicating that the t(1;2)(p22;p12) is a recurrent cytogenetic event in MALT lymphoma.
A 60-year-old Taiwanese lady presented with two abdominal wall masses for 1 month, and intermittent, productive cough for years. She was …
Published Online First 10 November 2006
Competing interests: None declared.
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