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Metanephric adenoma (MA) is a benign kidney tumour, accounting for about 0.2% of adult renal epithelial neoplasms.1 Development of MA from tubules of the fetal kidney and relationship with Wilm’s tumour (WT) were postulated despite lack of chromosome alterations typically found in WT.2,3 MA has been linked to papillary renal cell carcinoma (RCC) and the differentiation can be challenging in routine pathology. It has been suggested that MA is a distinct tumour entity with specific genetic alterations.4 Many cases do not seem clinically symptomatic.
An 18-year-old male Caucasian presented with polycythaemia (haemoglobin 25 g%) and an erythropoietin (EPO) level of 105 mU/ml (8.0–34.0 mU/ml) in a routine medical check-up. Bone-marrow biopsy ruled out haematological disorders. A CT scan demonstrated a contrast-enhancing mass 4 cm in diameter in the lateral middle section of the left kidney. An encapsulated, homogeneous, light-brown coloured tumour was removed and sent in for frozen section. The further course was uneventful.
A 44-year-old female patient, otherwise healthy, presented with subjective weakness. CT showed a mass 3 cm in diameter with contrast enhancement of the right kidney. The patient underwent a transperitoneal resection of the tumour; the further course was uneventful. No signs …
Published Online First: 10 November 2006
Competing interests: None.
Ethical approval: This study was approved by the University of Regensburg Ethics Committee.
Informed written consent was obtained from both patients in this study.
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