The postmortem examination of a multimalformed infant with trisomy D revealed 33 capillary hemangiomas in both lungs, with the microscopic features of the common cutaneous GLUT-1 infantile hemangioma. The finding further expands the spectrum of sites where this type of capillary hemangioma can be found, as it has been reported in the placenta, liver, salivary gland and mammary gland. Its association with the genetic condition trisomy D, already known to occasionally present cutaneous and hepatic hemangiomas, could be a clue to its pathogenesis.

Hemangiomas in children are most commonly recognised in the skin and liver. They are infrequent in the respiratory tract, presenting predominantly in the subglottic region, and extremely rare in the lung. Pulmonary hemangiomas include endobronchial and parenchymatous types. In accordance to its structure, they are classified as capillary and cavernous histological types.¹

Among the angiomatous lesions of childhood, the so-called infantile hemangioma (IH) shows a peculiar characteristic: its endothelial cells express the antigen GLUT-1^2–4. This feature allows differential diagnosis with other types of vascular tumours and malformations found at this age.

We are reporting the case of an infant with partial trisomy D presenting with a series of malformations already reported in this condition combined with the unique finding of multiple IH in both lungs.

Case report

This female newborn was referred from another medical centre 15 h after birth under assisted ventilation, with the tentative diagnosis of genetic syndrome and cyanotic congenital heart disease. She was born through caesarean section at 38 weeks gestational age. Birth weight was 2500 g and the Apgar was 4/7. The mother was 30 years old and presented with hypertension. After admission, an echocardiography demonstrated right ventricle with double outlet, pulmonary valve atresia, patent small ductus, subaortic ventricular septal defect with overriding aorta, dilated right atria and ventricle, dilated …