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Helicobacter pylori-associated peptic ulcer and florid follicular gastritis mimicking a malignancy
  1. Shih-Sung Chuang1,
  2. Chien-Feng Li2,
  3. Peter G Isaacson3
  1. 1Department of Pathology, Chi-Mei Medical Centre, Tainan, Taiwan; Department of Pathology, Taipei Medical University, Taipei
  2. 2Department of Pathology, Chi-Mei Medical Centre, Tainan, Taiwan
  3. 3Department of Histopathology, University College London, London, UK
  1. Correspondence to:
    Dr Shih-Sung Chuang
    Department of Pathology, Chi-Mei Medical Center, 901 Chung-Hwa Road, Yung-Kang City, Tainan County 710, Taiwan; cmh5301{at}

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In chronic follicular gastritis the lymphoid follicles are usually localised in the lamina propria.1 In lymphoid hyperplasia associated with a chronic peptic ulcer, numerous lymphoid follicles are sometimes present in the ulcer base, in which the muscularis propria has usually been destroyed and replaced by scar tissue.2 The histology of Helicobacter-associated chronic gastritis with numerous reactive lymphoid follicles and an indistinct poorly developed marginal zone may closely simulate lymphoma and pose a diagnostic challenge. We present an extreme example of florid follicular gastritis, which mimicked a malignant neoplasm clinically and pathologically. To our knowledge, such florid hyperplasia with reactive lymphoid follicles extending into the muscularis propria and beyond has never been reported.

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  • Competing interests: None declared.