Article Text

Download PDFPDF
Epithelioid perineurioma: an unusual variant
  1. S A Haider1,
  2. R J Lemberger2,
  3. C Fisher3,
  4. T A McCulloch1
  1. 1Department of Histopathology, Nottingham University Hospitals NHS Trust, UK
  2. 2Department of Urology, Nottingham University Hospitals NHS Trust, UK
  3. 3Department of Histopathology, Royal Marsden Hospital, London, UK
  1. Dr T A McCulloch, Department of Histopathology, City Hospital Campus, Nottingham University Hospitals NHS Trust, Hucknall Road, Nottingham NG5 1PB, UK; tom.mcculloch{at}


An unusual epithelioid variant of perineurioma of the groin occurring in a 53-year-old man is described. The lesion appeared to be associated with a femoral nerve branch. The tumour was characterised by the presence of a syncytial proliferation of epithelioid cells, mimicking a meningioma of syncytial type. In addition there was a minor component of a conventional perineurioma. The tumour cells were EMA+, claudin-1+ and collagen type IV+. Bcl 2 was focally expressed. This case highlights the possibility of a common histogenetic pathway for meningiomas and perineuriomas. Although ultrastructural evidence of possible meningiomatous differentiation within an otherwise histologically typical perineurioma has been described, this is the first reported case of an unconventional epithelioid variant of perineurioma, histologically resembling meningioma.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Competing interests: None.

  • Patient consent: Obtained.