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Acute post-streptococcal glomerulonephritis associated with prolonged hypocomplementaemia
  1. D Payne1,
  2. P Houtman2,
  3. M Browning1,3
  1. 1Department of Immunology, Leicester Royal Infirmary, Leicester, UK
  2. 2Children’s Hospital, Leicester Royal Infirmary, Leicester, UK
  3. 3Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, UK
  1. Mr D Payne, Department of Immunology, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK; daniel.payne{at}


The case of a 6-year-old boy who presented with acute post-streptococcal glomerulonephritis is reported. C3 levels and complement alternative pathway activity remained low for at least 10 months after presentation, before returning to normal. There was no evidence of other renal disease. This case highlights that hypocomplementaemia in acute post-streptococcal glomerulonephritis may persist for several months, and that prolonged hypocomplementaemia does not exclude this diagnosis.

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  • Competing interests: None.

  • Patient consent: Parental consent obtained.

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