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Neurologically presenting Whipple disease: case report and review of the literature
  1. M J Buckle1,
  2. R W Ellis2,
  3. M Bone2,
  4. H Lockman2
  1. 1Cardiff University, University Hospital of Wales, Heath Park, Cardiff
  2. 2South Tyneside NHS Foundation Trust, South Shields, Tyne and Wear, UK
  1. Mr M Buckle, University Hospital of Wales, Heath Park, Cardiff, UK; bucklemj{at}


A previously healthy male with subacute onset right leg weakness was suspected to have an astrocytoma as imaging showed a lesion. Subsequent biopsy showed the presence of foamy macrophages containing periodic acid-Schiff staining granules, suggesting Whipple disease as a possible diagnosis.

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  • Competing interests: None.

  • Patient consent: Obtained.