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In their recent article in this journal, Penman and colleagues investigated the possibility of thyroid transcription factor-1 (TTF-1) immunostaining among colorectal adenocarcinoma (CRC) using two monoclonal antibodies.1 They found the SPT24 clone, but not the 8G7G3/1 clone, to show nuclear staining among a proportion of CRCs. All previous peer-reviewed publications on the latter TTF-1 antibody have similarly reported a complete absence of staining among primary and metastatic CRC.2–5 We now present two cases of CRC that stained positively with the 8G7G3/1 monoclonal antibody, as verified by three independent laboratories.
Case 1 was a Caucasian man in his 60s who presented with a lower rectal tumour, biopsies of which showed CRC and background adenoma. He underwent neoadjuvant treatment, because of threatened mesorectal margins, …
Competing interests: None declared.
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