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Snippets in surgical pathology
  1. Kumarasen Cooper (,
  2. Runjan Chetty (

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Journal of Pathology, May 2009

Sluimer JC, Daemen MJ. Novel concepts in atherogenesis: angiogenesis and hypoxia in atherosclerosis. J Pathol 2009;218:7–29.

For pathologists interested in the micropathogenesis of plaque rupture/thrombus formation in atherogenesis, this review explores the role of angiogenesis and hypoxia (secondary to inflammation creating an increased oxygen demand) followed by microvessel endothelial destruction, intraplaque haemorrhage and ultimate rupture. Hence, clinically both angiogenesis and hypoxia present novel targets for non-invasive imaging of plaques at risk for rupture.

Sastre-Garau X, Peter M, Avril M-F, et al. Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis. J Pathol 2009;218:48–56.

This section features synopses of pertinent practical publications that appear in Pathology journals in the respective sub-specialties. The summaries are mere guidelines and personal opinions of the two authors. The articles selected are diverse but occasionally reflect the authors’ bias and are from the more widely read pathology journals. It is not intended to be an assiduous search of every publication in every Pathology journal, but more of a general indication of some of the monthly highlights through the eyes of the authors.

Hopefully, these snippets will provide the reader with enough to glean some facts and tips, as well as encourage them to read the entire article if necessary.

In the last few months a viral oncogenetic role for the pathogenesis of Merkel cell carcinoma has been proposed. This study explores 10 cases demonstrating the so-called Merkel cell virus (MCV) in an integrated physical state with no alteration of the adjacent cellular genes and a clonal pattern of the MCV integration pattern, presenting further evidence supporting a causative role for MCV in tumorigenesis.

Human Pathology, May 2009

Hruban R, Adsay NV. Molecular classification of neoplasms of the pancreas. Hum Pathol 2009;40:612–23.

The trend of …

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  • Provenance and peer review Commissioned; not externally peer reviewed.