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Venous invasion detection in colorectal cancer: which approach, which technique?
  1. G Puppa,
  2. A Caneva,
  3. R Colombari
  1. Division of Pathology, “G Fracastoro” City Hospital, Verona, Italy
  1. Giacomo Puppa, Division of Pathology, “G Fracastoro” City Hospital, Via Circonvallazione, 19, I-37047 San Bonifacio (VR), Italy; gpuppa{at}


Colorectal cancer is one of the most commonly diagnosed human malignancies and is a major cause of death worldwide. A high-quality macroscopic examination and histopathology report enables correct tumour staging, affects patient prognosis, and provides indications for further therapy. Although venous invasion is a stage-independent indicator of poor prognosis that identifies high-risk patients for visceral metastases, it is not a stage-influencing factor. Accordingly the use of special stains to facilitate the detection of venous invasion is not universally recommended and therefore not widely used in routine histopathological analysis. In this report based on a case presentation, the different approaches and techniques for detecting venous invasion are presented and discussed.

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  • Competing interests: None.

  • Patient consent: Obtained.