A case of intraosseous schwannoma of rib is presented. A 22-year-old woman was admitted with paroxysmal thoracic pain, unproductive cough and a hard mass of the thorax. CT scan showed a unilocular osteolystic lesion in the rib. A needle biopsy was performed, and a diagnosis of intraosseous schwannoma was made. The patient underwent a partial excision of rib and the tumour was removed. Macroscopic examination revealed a 4×2×1.5 cm solid lesion with destruction of bone. Microscopically, the tumour showed typical features of schwannoma characterised by Antoni A and Antoni B tissues and Verocay bodies. Immunohistochemically, the tumour was positive for S-100 protein, vimentin, neuron specific enolase (NSE) and glial fibrillary acidic protein (GFAP). The patient is well without local recurrence or metastasis after a 1-year follow-up. This is believed to be the second case report of primary schwannoma of rib.
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