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Chemotherapy induced carcinoma–adenoma regression in the caecum
  1. J E Abela1,
  2. D M Wright1,
  3. A Hennessy2,
  4. F Roberts3,
  5. J R Anderson1
  1. 1Department of Surgery, Southern General Hospital, Glasgow, UK
  2. 2Department of Oncology, Beatson Oncology Centre, Glasgow, UK
  3. 3Department of Pathology, Western Infirmary, Glasgow, UK
  1. Mr J E Abela, Department of Surgery, Southern General Hospital, 1345 Govan Road, Glasgow, UK; jeabela{at}


The case of a male patient with synchronous oesophago-gastric junction (OGJ) and caecal adenocarcinomas is reported. His management is described, particularly the administration of neoadjuvant chemotherapy targeting his upper gastrointestinal cancer. Synchronous gastrectomy and hemicolectomy were performed. Histopathological examination of the surgical specimen confirmed the OGJ cancer but only identified a caecal adenoma. This is believed to be the first description of chemotherapy induced reversal of the adenoma–carcinoma sequence.

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  • Competing interests: None.

  • Patient consent: Obtained.