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VEGF-A and i-NOS expression are prognostic factors in serous epithelial ovarian carcinomas after complete surgical resection
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    Which is the cart and which the horse?
    Which is the cart and which the horse?

    Dear Editor,

    In HL-60 cells lovastatin reduces the intracellular pH in dose- dependent manner and the fall in pH correlates with the extent of DNA degradation (1). More importantly alkalinization suppresses lovostatin-induced apoptosis. A fall in pH is an indication of reductive stress, a stimulus for the expression of HIF, VEGF and NOS. A normal or elevated pH may also be nece...

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    Conflict of Interest:
    None declared.