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Table 1

Table 1 CIOMS consensus criteria for terminology in drug-induced liver injury
TerminologyCriteria
Hepatocellular injuryIsolated increase in ALT >twice normal, or ALT/ALP ⩾5
Cholestatic injuryIsolated increase in ALP >twice normal, or ALT/ALP ⩽2
Mixed injuryALT and ALP are increased, and 2<ALT/ALP<5
Acute injuryAbove changes present for <3 months
Chronic injuryAbove changes present for >3 months
Chronic liver diseaseThis term is used only after histological confirmation

  • ALP, alkaline phosphatase; ALT, alanine aminotransferase; CIOMS, Council for International Organizations of Medical Sciences.

Vol 77 Issue 5 Table of Contents
Journal of Clinical Pathology: 77 (5)
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