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Spindle cell tumour with glandular elements: an unusual ileal neoplasm
  1. A C Bateman1,
  2. K Holgate2,
  3. B Green1,
  4. K Thway3,
  5. J Primrose4
  1. 1
    Department of Cellular Pathology, Southampton General Hospital, Southampton, UK
  2. 2
    Department of Infection and Population Health, Royal Free Hospital, London, UK
  3. 3
    Department of Histopathology, The Royal Marsden Hospital, London, UK
  4. 4
    University Department of Surgery, Southampton General Hospital, Southampton, UK
  1. Dr A C Bateman, Cellular Pathology Department, MP002, Level E, South Block, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK; adrian.bateman{at}


This report describes a tumour in the ileum with clinical features initially suggestive of a gastrointestinal stromal tumour (GIST). Histopathological examination revealed a biphasic tumour in which the spindle cell component showed immunohistochemical evidence of smooth muscle differentiation but without the characteristic profile of a GIST. A well-differentiated epithelial component was also present, comprising glandular structures with immunohistochemical features suggestive of Mullerian differentiation. Similar glandular differentiation has been described in uterine leiomyomas but not, to our knowledge, in tumours associated with the small bowel. None of the characteristic mutations of GISTs were identified in this case. There were no overt features of malignancy but, because of the unusual nature of the case, we assessed the biological behaviour as uncertain.

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  • Competing interests: None.