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Spontaneous regression of natural killer cell lymphoma
  1. Y Isobe,
  2. N Aritaka,
  3. M Sasaki,
  4. K Oshimi,
  5. K Sugimoto
  1. Department of Hematology, Juntendo University School of Medicine, Tokyo, Japan
  1. Koichi Sugimoto, Department of Hematology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan; ksugimot{at}


Spontaneous tumour regression is extremely rare in aggressive lymphoma. A case of natural killer (NK) cell lymphoma with cutaneous manifestation showed an indolent clinical course, and the relapsed nodular lesion disappeared spontaneously without any treatment. Although only small number of T cells were present in the primary skin lesion, there was massive CD8-positive cytotoxic T cell infiltration in the relapsed lesion. This is believed to be the first report of an abscopal effect on NK cell lymphoma. Infiltration of cytotoxic T cells strongly suggests immunological attack against the lymphoma cells.

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  • Competing interests: None.

  • Ethics approval: Ethics approval was obtained from the Juntendo University institutional review board.

  • Patient consent: Obtained.