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Correlation of autoantibodies and CD5+ B cells in ocular adnexal marginal zone B cell lymphomas
  1. T Kubota1,
  2. S Moritani2,
  3. T Yoshino3,
  4. H Nagai4,
  5. H Terasaki5
  1. 1
    Department of Ophthalmology, National Hospital Organization, Nagoya Medical Center, Nagoya, Japan
  2. 2
    Department of Pathology, National Hospital Organization, Nagoya Medical Center, Nagoya, Japan
  3. 3
    Department of Pathology, Okayama University Graduate School of Medical, Dentistry and Pharmaceutical Science, Okayama, Japan
  4. 4
    Department of Internal Medicine, National Hospital Organization, Nagoya Medical Center, Nagoya, Japan
  5. 5
    Department of Ophthalmology, Nagoya University Medical School, Nagoya, Japan
  1. Correspondence to Toshinobu Kubota, Department of Ophthalmology, National Hospital Organization, Nagoya Medical Center, 4-1-1, Sannomaru, Naka-ku, Nagoya-shi, Aichi-ken, 460-0001, Japan; ganiky{at}nnh.hosp.go.jp

Abstract

Aim: To determine the clinicopathological properties of ocular adnexal marginal zone B cell lymphomas (MZBLs) with CD5+ B cells.

Methods: This study determined the clinicopathological properties of MZBL samples from 97 patients with ocular adnexal MZBLs and searched for hallmarks of systemic autoimmunity in these patients.

Results: Two elderly female patients were found to have ocular adnexal MZBLs with CD5+ B cells; flow cytometry analysis suggested that one of these MZBLs had CD5+ B cell clonal proliferation. The levels of anti-single stranded (SS)-DNA and anti-SS-A/Ro antibodies in these two patients were significantly higher than those in controls that were matched for age, gender and disease (2/2 versus 0/14; p = 0.008) and controls without MZBL (2/2 versus 0/30; p = 0.002). The genes from the immunoglobulin heavy-chain variable region for one of the patients showed a V3-21 segment. In addition, another patient with ocular adnexal reactive lymphoid hyperplasia with CD5+ B cells also had anti-SS-DNA antibodies.

Conclusion: Patients with ocular adnexal MZBLs with CD5+ B cells may have a background of systemic conditions with CD5+ B-cell-related autoantibodies.

https://doi.org/10.1136/jcp.2009.067603

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    Footnotes

    • Competing interests None.

    • Ethics approval Ethics approval was obtained from the Ethics Committee at Nagoya Medical Center, Nagoya, Japan.

    • Provenance and Peer review Not commissioned; externally peer reviewed.