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  • MTOC-MT is a major target antigen of autoantibody detected by autoimmune target tests in patients with hepatitis A virus infection

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Letter to the editor
MTOC-MT is a major target antigen of autoantibody detected by autoimmune target tests in patients with hepatitis A virus infection
  1. Jung-UK Sir1,
  2. Think-You Kim2
  1. 1Institute of Rheumatism, The Hospital for Rheumatic Diseases, Hanyang University Medical Center, Seoul, South Korea
  2. 2Department of Early Arthritis/Laboratory Medicine, The Hospital for Rheumatic Diseases, Hanyang University Medical Center, Seoul, South Korea
  1. Correspondence to Professor Think-You Kim, Department of Early Arthritis/Laboratory Medicine, The Hospital for Rheumatic Diseases, Hanyang University Medical Center, 17 Haengdang-Dong Sungdong-Gu, Seoul 133-792, South Korea; tykim{at}hanyang.ac.kr

https://doi.org/10.1136/jcp.2009.069880

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    After reading a recent article by Moon et al,1 we offer our experience and opinion in relation to autoimmunity because we observed a rather different result in our hepatitis A virus (HAV) patients when we applied the new autoantibody detection method—the autoimmune target (AIT) test.

    In above paper, 65 of 73 (89.0%) HAV patients were positive in the antinuclear antibody (ANA) test; among them, 63 (95.5%) were interpreted to have ‘filamentous staining of cytoplasmic fibres similar to anti-actin patterns’.

    Korea is no longer an endemic area of HAV due to dramatically improved public sanitation followed by rapid economic growth. Hence, presentation of the disease has changed to the kind seen in more developed countries. Recently, however, minor outbreaks have occurred in the adult group …

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    Footnotes

    • Competing interests TY Kim holds patent relating to the IT-1 cell line.

    • Provenance and peer review Not commissioned; externally peer reviewed.