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My approach to cardiothoracic transplantation and the role of the histocompatibility and immunogenetics laboratory in a rapidly developing field
  1. Vaughan Carter
  1. Correspondence to Dr Vaughan Carter, National Health Service Blood and Transplant, Holland Drive, Barrack Road, Newcastle upon Tyne NE2 4NQ, UK; vaughan.carter{at}


Cardiothoracic transplantation presents specific challenges. The lack of long-term replacement therapy (such as dialysis for kidney patients) creates a more urgent situation than for other forms of transplantation, necessitating a different approach. This review looks at ways in which the challenges are being met and the integral role of the histocompatibility and immunogenetics laboratory.

  • HLA
  • antibodies
  • heart transplantation
  • lung transplantation
  • virtual cross-match
  • heart

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  • Competing interests None.

  • Provenance and peer review Commissioned; externally peer reviewed.